ABSTRACT
Testicular volume (TV) is considered a good clinical marker of hormonal and spermatogenic function. Accurate reference values for TV measures in infertile and fertile men are lacking. We aimed to assess references values for TV in white-European infertile men and fertile controls. We analyzed clinical and laboratory data from 1940 (95.0%) infertile men and 102 (5.0%) fertile controls. Groups were matched by age using propensity score weighting. TV was assessed using a Prader orchidometer (PO). Circulating hormones and semen parameters were investigated in every male. Descriptive statistics, Spearman's correlation, and logistic regression models tested potential associations between PO-estimated TV values and clinical variables. Receiver operating characteristic (ROC) curves were used to find TV value cutoffs for oligoasthenoteratozoospermia (OAT) and nonobstructive azoospermia (NOA) status in infertile men. The median testicular volume was smaller in infertile than that of fertile men (15.0 ml vs 22.5 ml; P < 0.001). TV positively correlated with total testosterone, sperm concentration, and progressive sperm motility (all P ≤ 0.001) in infertile men. At multivariable logistic regression analysis, infertile status (P < 0.001) and the presence of left varicocele (P < 0.001) were associated with TV < 15 ml. Testicular volume thresholds of 15 ml and 12 ml had a good predictive ability for detecting OAT and NOA status, respectively. In conclusion, infertile men have smaller testicular volume than fertile controls. TV positively correlated with total testosterone, sperm concentration, and progressive motility in infertile men, which was not the case in the age-matched fertile counterparts.
ABSTRACT
PURPOSE: Measurement of testicular volume is useful for the evaluation of puberty and testicular development in boys. Four mililiter of testicular volume means Tanner stage 2, the beginning of puberty, and its ethnic differences were reported. However, there is no reference value for Korean children. We tried to establish the standard testicular volume for Korean boys. METHODS: The subjects were selected among the children who visited the out-patient clinic of Kangdong Sacred Heart Hospital and Korea Cancer Center Hospital for the evaluation of growth from 2003 to 2008. Three hundred seventy two healthy Korean boys, 3 to 17 years of age, were included. We excluded the patients who were diagnosed as precocious puberty, delayed puberty, hypopituitarism, adrenal disorder and other endocrinologic disorder. The testicular volume was determined with Prader orchidometer. Clinical data were collected from patient's chart retrospectively. RESULTS: Right and left testicular volumes were 3.65 +/- 1.82 mL and 3.55 +/- 1.80 mL at 10 (10.0 - 10.9) year of age (n = 53), 6.17 +/- 3.60 mL and 6.13 +/- 3.69 mL at 11 (11.0 - 11.9) year of age (n = 52), respectively. There was no significant difference between right and left testicular volumes. CONCLUSION: The time when testicular volume reached 4 mL seemed to be not changed than previous Korean data. However, further study will be required to determine the secular trend of pubertal timing in Korean boys.
Subject(s)
Child , Humans , Heart , Hypopituitarism , Korea , Outpatients , Puberty , Puberty, Delayed , Puberty, Precocious , Reference Values , Retrospective StudiesABSTRACT
PURPOSE: The aim of this study was to compare testicular volumes measured by Prader orchidometer and scrotal ultrasound. MATERIALS AND METHODS: The volumes of 467 adult male testes were measured by Prader orchidometer and scrotal ultrasound. The testicular volumes on ultrasound were calculated by the formula: length x width x height x 0.71. The testicular volumes of the Prader orchidometer were divided into two groups: 15 ml or less, and over 15 ml. The two measurements were compared for each group. RESULTS: In the group with testicular volumes of 15 ml or less, the testicular volumes measured by orchidometer(13.29+/-1.94 ml) were significantly smaller than those measured by ultrasound(14.83+/-2.76 ml). In contrast, the group with over 15 ml did not show any significant difference in the volumes measured by orchidometer(21.21+/-2.58 ml) versusultrasound(20.77+/-4.26 ml). Mean paired differences of the testicular volumes between the orchidometer and ultrasound were 1.54+/-2.65 ml for the group with 15 ml or less and -0.44+/-3.38 ml for the group over15 ml these values are significantly different. CONCLUSIONS: In cases of testicular volume of 15 ml or less measured by Prader orchidometer, scrotal ultrasound is necessary for an accurate measurement of the volume.